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What is real love like?! Do you know the answer?! more. NO MEN PLEASE!! The presence of small but detectable pulses of luteinizing hormone induced by gonadotropin-releasing hormone in the patient with the RX and XR mutations and his leftward-shifted dose—response curve suggest that pituitary responsiveness in the GPRdeficient patient is, if anything, enhanced, suggesting that loss-of-function mutations in GPR54 do not diminish the sensitivity of gonadotropes to gonadotropin-releasing hormone. Colonies were grown, and their DNA sequenced.
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The dose—response curve for the proband is shifted leftward as compared with the 95 percent confidence intervals around the mean responses in men with idiopathic hypogonadotropic hypogonadism who did not have any GPR54 mutations. Together, we have been focusing on the best ways to develop new therapies and optimize prescribing by steering patients to the right drug at the right dose at the right time. The possibility remains, however, that there is a subtle defect in the terminal migration or differentiation of these neurons within the hypothalamus. Our data from patients with idiopathic hypogonadotropic hypogonadism and a mouse model provide strong evidence that GPR54 is a key regulator of the biology of puberty. Such a resource will allow for a much broader assessment of the clinical importance of genetic variation across a range of conditions.
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